Tangeretin | B3350

Tangeretin | B3350

Description: Tangeretin is a methoxyflavone compound isolated from citrus fruits that demonstrates antiproliferative and antioxidant effects. It inhibits signaling in cancer cells, reducing ERK phosphorylation and growth of estradiol-stimulated T47D breast cancer cells (IC50 ~ 3 μM) and blocking p38 MAPK, JNK, and Akt activation in interleukin-1β-stimulated human lung carcinoma A549 cells. Tangeritin activates the pregnane X receptor, inducing MDR1 expression in human colonic LS180 cancer cells at a concentration of 10 μM. Recently, tangeretin has also been found to significantly reduce serum total and LDL cholesterol and triacylglycerols in hypercholesteremic hamsters.

Alternate Name/Synonyms: 5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one NSC 53909 NSC 618905 Ponkanetin

Appearance: Solid

Formulation:

CAS Number: 481-53-8

Structure Available?: Yes

Peptide sequence:

Salt Form: No

Molecular Formula: C₂₀H₂₀O₇

Molecular Weight: 372.4

Cell-Permeable?: TRUE

Purity: ≥96% by HPLC

Solubilities: >10 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Tag Line: A biologically active methoxyflavone

MDL Number: MFCD00017438

PubChem CID: 68077

PubChem CID Link: https://pubchem.ncbi.nlm.nih.gov/compound/68077

SMILES: COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)OC)OC

InChi: InChI=1S/C20H20O7/c1-22-12-8-6-11(7-9-12)14-10-13(21)15-16(23-2)18(24-3)20(26-5)19(25-4)17(15)27-14/h6-10H,1-5H3

InChi Key: ULSUXBXHSYSGDT-UHFFFAOYSA-N

Category: