Tanshinone IIA-Sulfonic Sodium | B1902

Sodium tanshinone IIA sulphonate (T06) is a water-soluble derivative of tanshinone IIA, that displays versatile biological properties. Recently, it has been shown to act as an ectosteric inhibitor of cathepsin K (CatK). T06 binds in an ectosteric side of Cathepsin K remote from its active site and selectively inhibits collagen degradation. It also inhibits bone resorption in ovariectomized mice.

Sodium tanshinone IIA sulphonate (T06) is a water-soluble derivative of tanshinone IIA, that displays versatile biological properties. Recently, it has been shown to act as an ectosteric inhibitor of cathepsin K (CatK). T06 binds in an ectosteric side of Cathepsin K remote from its active site and selectively inhibits collagen degradation. It also inhibits bone resorption in ovariectomized mice.

B1902 | Tanshinone IIA-Sulfonic Sodium DataSheet

Alternate Name/Synonyms: Sodium tanshinone IIA sulfonate; Sulfotanshinone sodium II-A; T06

Appearance: Off-white to orange red powder

Formulation: N/A

CAS Number: 69659-80-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₇NaO₆S

Molecular Weight: 396.39

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO or H₂O (~5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent ectosteric inhibitor of cathepsin K (CatK)

MDL Number: MFCD09028094

PubChem CID: 23669322

SMILES: CC1=C(OC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C)S(=O)(=O)[O-].[Na+]

InChi: InChI=1S/C19H18O6S.Na/c1-9-13-15(20)16(21)14-10-5-4-8-19(2,3)12(10)7-6-11(14)17(13)25-18(9)26(22,23)24;/h6-7H,4-5,8H2,1-3H3,(H,22,23,24);/q;+1/p-1

InChi Key: AZEZEAABTDXEHR-UHFFFAOYSA-M