Tartrate Resistant Acid Phosphatase polyclonal Antibody | BS65566

Tartrate Resistant Acid Phosphatase polyclonal Antibody | BS65566 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB,

Application Range: WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

Background: Tartrate-resistant acid phosphatase is an iron containing glycoprotein that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. TRAP is the most basic of the acid phosphatases and is the only form not inhibited by L+-tartrate. TRAP is a relatively minor lysosomal enzyme which may be activated in certain pathologies such as Hodgkin’s disease and B- and T-cell leukemias. Receptor activator of NFκB ligand (RANKL) plays an essential role in osteoclast differentiation and activation by increasing the expression of protease osteoclast markers such as TRAP. TRAP has collagenolytic activity and plays a major role in ligament degradation.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Tartrate Resistant Acid Phosphatase polyclonal Antibody detects endogenous levels of Tartrate Resistant Acid Phosphatase protein.

Molecular Weight: ~36kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Type 5 acid phosphatase; Acid phosphatase 5 tartrate resistant; ACP5; PPA5_HUMAN; T5ap; Tartrate resistant acid ATPase; Tartrate resistant acid phosphatase type 5; Tartrate resistant acid phosphatase type 5 precursor; Tartrate-resistant acid ATPase; Tartrate-resistant acid phosphatase type 5; TR AP; TR-AP; TrATPase; Type 5 acid phosphatase.

Immunogen: KLH conjugated synthetic peptide derived from human Tartrate Resistant Acid Phosphatase :211-310/325

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: