TAS-109 | B3327

TAS-109 is a novel deoxycitidine analog that inhibits DNA polymerase resulting in S-phase arrest, while prolonged exposure to TAS-109 at low concentration causes DNA fragmentation, G2/M phase arrest and apoptosis. TAS-109 displays activity in tumor xenografts resistant to other deoxycitidine analogs.

TAS-109 is a novel deoxycitidine analog that inhibits DNA polymerase resulting in S-phase arrest, while prolonged exposure to TAS-109 at low concentration causes DNA fragmentation, G2/M phase arrest and apoptosis. TAS-109 displays activity in tumor xenografts resistant to other deoxycitidine analogs.

B3327 | TAS-109 DataSheet

Alternate Name/Synonyms: (2R,3S,4S,5R)-2-(4-amino-2-oxopyrimidin-1-yl)-4-hydroxy-5-(hydroxymethyl)oxolane-3-carbonitrile DFP-10917 TAS109 CNDAC

Appearance: Solid

Formulation:

CAS Number: 135598-68-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₀H₁₂N₄O₄

Molecular Weight: 252.23

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A DNA polymerase inhibitor

MDL Number:

PubChem CID: 119184

SMILES: N#C[C@@H]1[C@H](N2C=CC(N)=NC2=O)O[C@H](CO)[C@H]1O

InChi: InChI=1S/C10H12N4O4/c11-3-5-8(16)6(4-15)18-9(5)14-2-1-7(12)13-10(14)17/h1-2,5-6,8-9,15-16H,4H2,(H2,12,13,17)/t5-,6+,8-,9+/m0/s1

InChi Key: DCYBPMFXJCWXNB-JWIUVKOKSA-N