Description
TAS-109 is a novel deoxycitidine analog that inhibits DNA polymerase resulting in S-phase arrest, while prolonged exposure to TAS-109 at low concentration causes DNA fragmentation, G2/M phase arrest and apoptosis. TAS-109 displays activity in tumor xenografts resistant to other deoxycitidine analogs.
TAS-109 is a novel deoxycitidine analog that inhibits DNA polymerase resulting in S-phase arrest, while prolonged exposure to TAS-109 at low concentration causes DNA fragmentation, G2/M phase arrest and apoptosis. TAS-109 displays activity in tumor xenografts resistant to other deoxycitidine analogs.
Alternate Name/Synonyms: (2R,3S,4S,5R)-2-(4-amino-2-oxopyrimidin-1-yl)-4-hydroxy-5-(hydroxymethyl)oxolane-3-carbonitrile DFP-10917 TAS109 CNDAC
Appearance: Solid
Formulation:
CAS Number: 135598-68-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₀H₁₂N₄O₄
Molecular Weight: 252.23
Cell-Permeable?: TRUE
Purity: ≥98%
Solubilities: DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A DNA polymerase inhibitor
MDL Number:
PubChem CID: 119184
SMILES: N#C[C@@H]1[C@H](N2C=CC(N)=NC2=O)O[C@H](CO)[C@H]1O
InChi: InChI=1S/C10H12N4O4/c11-3-5-8(16)6(4-15)18-9(5)14-2-1-7(12)13-10(14)17/h1-2,5-6,8-9,15-16H,4H2,(H2,12,13,17)/t5-,6+,8-,9+/m0/s1
InChi Key: DCYBPMFXJCWXNB-JWIUVKOKSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |