TAU Antibody | 8077

TAU Antibody | 8077 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: TAU antibody was raised against a 19 amino acid peptide near the amino terminus of human TAU.
The immunogen is located within amino acids 210 - 260 of TAU.

Research Area: Neuroscience

Tested Application: E, WB, IHC-P

Application: TAU antibody can be used for detection of TAU by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in human and rat samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Specificiy: TAU antibody is human, mouse and rat reactive. Multiple isoforms of TAU are known to exist; this antibody will only detect the two longest isoforms.

Positive Control 1: Cat. No. 1220 - SK-N-SH Cell Lysate

Positive Control 2: Cat. No. 1463 - Rat Brain Tissue Lysate

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 83 kDa
Observed: 90 kDa

Validation: N/A

Isoform: N/A

Purification: TAU antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: TAU antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: TAU antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: Microtubial-associated protein tau, MAPT, MAPTL, DDPAC, FTDP-17L, MSTD, MTBT1, MTBT2, PPND, PPP1R103

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The microtubial-associated protein TAU (MAPT) , more commonly known as TAU, is is normally a highly soluble protein found predominantly in neurons (1) , but accumulations of highly phosphorylated tau protein aggregates are observed in several neurodegenerative diseases including Alzheimer’s disease, progressive supranuclear palsy, corticobasal degeneration, and frontotemporal lobar dementia. It was thought that these pathological tau aggregates were the toxic form of tau, but recent studies indicate that soluble and highly phosphorylated tau species are more closely associated with synaptic dysfunction and cell loss (2, 3) . Mutations in the TAU gene have also been associated with several of these neurodegenerative diseases (4) .