TBC1D4 Antibody | 4415

TBC1D4 Antibody | 4415 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: Predicted species reactivity based on immunogen sequence: Mouse: (89%)

Immunogen: TBC1D4 antibody was raised against an 19 amino acid peptide near the carboxy terminus of human TBC1D4 .
The immunogen is located within amino acids 1190 - 1240 of TBC1D4.

Research Area: Homeostasis

Tested Application: E, IHC-P

Application: TBC1D4 antibody can be used for immunohistochemistry starting at 10 μg/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

Specificiy: N/A

Positive Control 1: Cat. No. 10-635 - Human Prostate Tissue Slide

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 143 kDa
Observed: 140 kDa

Validation: N/A

Isoform: N/A

Purification: TBC1D4 Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: TBC1D4 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: TBC1D4 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: TBC1D4 Antibody: AS160, AS160, KIAA0603, TBC1 domain family member 4, Akt substrate of 160 kDa

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: TBC1D4 Antibody: TBC1D4, also known as the Akt substrate AS160, was initially identified as an Akt substrate containing a GTPase-activating domain that regulates GLUT4 trafficking, with activation following insulin stimulation. TBC1D4 truncations in humans is a major cause of dominant inherited insulin resistance. The loss of TBC1D4 results in the accumulation of GLUT4 in compartments that are primed for fusion in basal adipocytes.