TCF3 Antibody (C-term) [AMM08128G]

TCF3 Antibody (C-term) [AMM08128G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This TCF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 506-534 amino acids from the C-terminal region of human TCF3.

Cellular Localisation: Nucleus {ECO:0000250|UniProtKB:P15806}.

Molecular Weight: 67600

Clone: Polyclonal

Gene Name: TCF3

Gene ID: 6929

Function: Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Together with TCF15, required for the mesenchymal to epithelial transition. Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity) . Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990) . Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, FC, IHC-P

Dilution: WB--1:1000 FC--1:10~50 IHC-P--1:100~500

Synonyms: Transcription factor E2-alpha, Class B basic helix-loop-helix protein 21, bHLHb21, Immunoglobulin enhancer-binding factor E12/E47, Immunoglobulin transcription factor 1, Kappa-E2-binding factor, Transcription factor 3, TCF-3, Transcription factor ITF-1, TCF3, BHLHB21, E2A, ITF1