TCF7 Polyclonal Antibody | E-AB-53275

TCF7 Polyclonal Antibody | E-AB-53275 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: FLJ36364, MGC47735, OTTHUMP00000159391, T cell factor 1, T cell specific transcription factor 1, T-cell factor 1, T-cell-specific transcription factor 1, TCF-1, TCF-7, TCF1, Tcf7, TCF7 transcription factor 7, TCF7, Transcription factor 7 (T cell specific HMG box), Transcription factor 7, Transcription factor-7, T-cell specific, Transcription factor-7, T-cell specific, 1

Application: IHC, ELISA

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Epigenetics and Nuclear Signaling, Immunology, Stem Cells

Background: This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling.

Concentration: 0.78 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of human TCF7

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: IHC 1:40-1:200, ELISA 1:5000-1:10000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A