TCF7L2 polyclonal Antibody | BS91324

TCF7L2 polyclonal Antibody | BS91324 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC/IF IHC IP FC

Application Range: WB:1:500-1:1,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Background: T cell factors (TCFs) comprise a family of DNA-binding transcriptional activators that are essential for lymphoid cell development. These transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, which mediates DNA binding. TCF-4 mainly localizes in the cytoplasm and is transported into the nucleus directly bound to β-catenin in a cooperative manner. This TCF-4/β-catenin complex induces expression of Wnt target genes, including multiple cancer-associated genes. c-Jun also interacts with TCF-4 and β-catenin, and the phosphorylation-dependent interaction between c-Jun and TCF4 regulates intestinal tumorigenesis by integrating JNK and APC/β-catenin. TCF-4 is also implicated in bipolar affective disorder.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: TCF7L2 polyclonal Antibody detects endogenous levels of TCF7L2 protein.

Molecular Weight: 68 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: T-cell factor 4, TCF-4, hTCF-4, TCF7L2, HMG box transcription factor 4, hTCF 4, hTCF-4, T cell factor 4, T cell specific HMG box, T cell specific transcription factor 4, T-cell factor 4, T-cell-specific transcription factor 4, TCF 4, TCF-4, TCF4, TCF7L2, TCF7L2 protein, TF7L2, Transcription factor 7 like 2, Transcription factor 7 like 2 T cell specific HMG box, Transcription factor 7-like 2,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: