TCS 5861528 | B2977

TCS 5861528 is a selective transient receptor potential ankyrin 1 (TRPA1) blocker that antagonizes TRPA1-mediated calcium influx induced by allyl isothiocyanate and 4-hydroxy nonenal with IC₅₀ values of 14.3 and 18.7 μM, respectively. Chronic administration of TCS 5861528 (30 mg/kg twice daily) in diabetic rats attenuates pain-related behavior and development of mechanical hypersensitivity.

TCS 5861528 is a selective transient receptor potential ankyrin 1 (TRPA1) blocker that antagonizes TRPA1-mediated calcium influx induced by allyl isothiocyanate and 4-hydroxy nonenal with IC₅₀ values of 14.3 and 18.7 μM, respectively. Chronic administration of TCS 5861528 (30 mg/kg twice daily) in diabetic rats attenuates pain-related behavior and development of mechanical hypersensitivity.

B2977 | TCS 5861528 DataSheet

Alternate Name/Synonyms: N-(4-butan-2-ylphenyl)-2-(1,3-dimethyl-2,6-dioxopurin-7-yl)acetamide; Chembridge-5861528; 1,2,3,6-tetrahydro-1,3-dimethyl-N-[4-(1-methylpropyl)phenyl]-2,6-dioxo-7H-purine-7-acetamide; 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide

Appearance: Solid

Formulation:

CAS Number: 332117-28-9

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₁₉H₂₃N₅O₃

Molecular Weight: 369.42

Cell-Permeable?: True

Purity: 97%

Solubilities: ~15 mg/ml in in DMSO, May need ultrasonication or warming in 0, ~30 mg/ml in DMF in 0, ~0.1 mg/ml in in Ethanol

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A selective TRPA1 blocker

MDL Number:

PubChem CID: 2873523

SMILES: CCC(C)C1=CC=C(C=C1)NC(=O)CN2C=NC3=C2C(=O)N(C(=O)N3C)C

InChi: InChI=1S/C19H23N5O3/c1-5-12(2)13-6-8-14(9-7-13)21-15(25)10-24-11-20-17-16(24)18(26)23(4)19(27)22(17)3/h6-9,11-12H,5,10H2,1-4H3,(H,21,25)

InChi Key: ZUTUWJYMCADJHD-UHFFFAOYSA-N