TDE1 (R392) polyclonal Antibody | BS2051

TDE1 (R392) polyclonal Antibody | BS2051 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: IHC

Application Range: IHC: 1:50~1:200

Background: TDE1, tumor differentially expressed protein 1, is a multi-pass membrane protein also known as serine incorporator 3. Also found on the membranes of the Golgi apparatus within cells, TDE1 is highly expressed in neuronal populations but is also found in thymus, kidney, liver and testis. Expression levels of TDE1 in tumors can be as much as tenfold the amount found in normal tissue of the same type. This increased expression implicates TDE1 as being involved in the cellular transformation from normal to malignant tissue. It is believed TDE1 contributes to oncogenesis by partially protecting cells from serum starvation and etoposide-induced apoptosis. The mechanism through which TDE1 protects cells is poorly understood, but may involve aberrant methylation of TDE1 complexes.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: TDE1 (R392) polyclonal Antibody detects endogenous levels of TDE1 protein.

Molecular Weight: ~ 53 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Serine incorporator 3; Tumor differentially expressed protein 1; SERINC3; DIFF33; TDE1; SBBI99

Immunogen: Synthetic peptide, corresponding to amino acids 360-412 of Human TDE1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Phospholipase Signaling,Phospholipase Signaling,Contribution of Soluble Factors to EMT,G Protein-coupled Receptors Signaling to MAPK Erk,Mitochondrial Control of Apoptosis,ErbB HER Signaling,