TDP43 polyclonal Antibody | BS91326

TDP43 polyclonal Antibody | BS91326 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat, Zebrafish

Application: WB IP ICC/IF IHC FC

Application Range: WB:1:1,000-1:5,000 ICC:1:100-1:500 IHC:1:50-1:200 FC:1:50-1:100 IP:1:10-1:50

Background: DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: TDP43 polyclonal Antibody detects endogenous levels of TDP43 protein.

Molecular Weight: 45 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: RNA polymerase II subunit B1, POLR2A, ALS10, OTTHUMP00000002171, OTTHUMP00000002172, OTTHUMP00000002173, TADBP, TAR DNA binding protein 43, TAR DNA binding protein, TAR DNA-binding protein 43, TARDBP, TDP 43, TDP-43, TDP43,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: