TECPR1 Antibody (C-term) [APR05902G]

TECPR1 Antibody (C-term) [APR05902G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This TECPR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1094-1122 amino acids from the C-terminal region of human TECPR1.

Cellular Localisation: Cytoplasmic vesicle, autophagosome membrane. Lysosome membrane. Note=Localizes to Lysosome membranes, and binds PtdIns (3) P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes

Molecular Weight: 129696

Clone: Polyclonal

Gene Name: TECPR1

Gene ID: 25851

Function: Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns (3) P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: IHC-P, FC, WB

Dilution: IHC-P--1:100 WB--1:500

Synonyms: Tectonin beta-propeller repeat-containing protein 1, TECPR1, KIAA1358