Telotristat | B3386

Telotristat | B3386

Description: Telotristat is an oral, small molecule inhibitor of tryptophan hydroxylase 1 (TPH1) IC50 = 16 nM) that is used in the treatment of symptoms of carcinoid syndrome.

Alternate Name/Synonyms: P778902 4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine

Appearance: Solid

Formulation:

CAS Number: 1033805-28-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₂₂ClF₃N₆O₃

Molecular Weight: 546.9

Cell-Permeable?: True

Purity: ≥98%

Solubilities: ~10 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Tag Line: A tryptophan hydroxylase 1 (TPH1) inhibitor

MDL Number:

PubChem CID Link:

SMILES: NC1=NC(C2=CC=C(C[C@H](N)C(O)=O)C=C2)=CC(O[C@H](C3=CC=C(Cl)C=C3N4C=CC(C)=N4)C(F)(F)F)=N1

InChi: InChI=1S/C25H22ClF3N6O3/c1-13-8-9-35(34-13)20-11-16(26)6-7-17(20)22(25(27,28)29)38-21-12-19(32-24(31)33-21)15-4-2-14(3-5-15)10-18(30)23(36)37/h2-9,11-12,18,22H,10,30H2,1H3,(H,36,37)(H2,31,32,33)/t18-,22+/m0/s1

InChi Key: NCLGDOBQAWBXRA-PGRDOPGGSA-N

Category: Biochemicals