TENM1 Antibody | 8149

TENM1 Antibody | 8149 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: Predicted species reactivity based on immunogen sequence: Chicken: (83%)

Immunogen: TENM1 antibody was raised against an 18 amino acid peptide near the amino terminus of human TENM1.
The immunogen is located within the first 50 amino acids of TENM1.

Research Area: Stem Cell, Neuroscience

Tested Application: E, WB, IHC-P, IF

Application: TENM1 antibody can be used for detection of TENM1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Specificiy: TENM1 antibody is human, mouse and rat reactive. TENM1 antibody is predicted to not cross-react with other members of the TENM family.

Positive Control 1: Cat. No. 1303 - Human Brain Tissue Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 301 kDa
Observed: 280 kDa

Validation: N/A

Isoform: N/A

Purification: TENM1 antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: TENM1 antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: TENM1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: Teneurin transmembrane protein 1, teneurin-1, ODZ1, ODZ3, TEN-M1, TNM, TNM1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The teneurin transmembrane protein 1 (TENM1) is a member of a family of four neuronal cell surface proteins homologous to the Drosophila pair-rule gene Ten-m (1, 2) . TENM1 is expressed primarily in the developing central nervous system and may be proteolytically cleaved with the intracellular domain translocating to the nucleus (3) . TENM1 is a direct target of the homeobox transcription factor EMX2, a transcription factor thought to be important for area specification in the developing cortex (4) .