Tenovin-1 | 9400

Tenovin-1 is a small molecule p53 activator that protects against MDM2-mediated p53 degradation. It acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Elevates levels of p53 and p21CIP/WAF1 and induces expression from an endogenous p53-dependent promoter. Exhibits potent antiproliferative activity in vitro.

Tenovin-1 is a small molecule p53 activator that protects against MDM2-mediated p53 degradation. It acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Elevates levels of p53 and p21CIP/WAF1 and induces expression from an endogenous p53-dependent promoter. Exhibits potent antiproliferative activity in vitro.

9400 | Tenovin-1 DataSheet

Alternate Name/Synonyms: N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide

Appearance: White solid

Formulation: N/A

CAS Number: 380315-80-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₃N₃O₂S

Molecular Weight: 369.48

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 8 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A p53 activator

MDL Number: MFCD02914760

PubChem CID: 1013376

SMILES: CC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C

InChi: InChI=1S/C20H23N3O2S/c1-13(24)21-16-9-11-17(12-10-16)22-19(26)23-18(25)14-5-7-15(8-6-14)20(2,3)4/h5-12H,1-4H3,(H,21,24)(H2,22,23,25,26)

InChi Key: WOWJIWFCOPZFGV-UHFFFAOYSA-N