TERT polyclonal Antibody | BS91329

TERT polyclonal Antibody | BS91329 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB FC

Application Range: WB:1:1,000-1:2,000 FC:1:50-1:100

Background: Telomerase is an RNA-dependent DNA polymerase that catalyzes the addition of telomeric repeat sequences to chromosome ends. In most human somatic cells, telomerase activity is undetectable, and telomeres shorten with successive cell divisions. However, telomerase activity is detectable in immortal cells and in many human tumors. Two candidate mammalian telomerase proteins have been cloned. Human TP1 (for telomerase-associated protein 1), also designated TLP1 in rat (for telomerase protein component 1), is homologous to the Tetrahymena p80 telomerase protein and has been shown to interact with mammalian telomerase RNA. Human TERT (for telomerase reverse transcriptase), also designated hEST2 (for ever shorter telomeres), is homologous to the p123 telomerase protein from Euplotes and to the yeast Est2 protein. Expression of TERT mRNA has been shown to correlate with telomerase activity in various cell lines.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: TERT polyclonal Antibody detects endogenous levels of TERT protein.

Molecular Weight: 127/120/90/89 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: TP2, TERT, CMM9, DKCA2, DKCB4, EST2, HEST2, htert, hTRT, PFBMFT1, TCS1, Telomerase associated protein 2, Telomerase catalytic subunit, Telomerase reverse transcriptase, Telomerase-associated protein 2, Telomere Reverse Transcriptase, TERT, TERT, TP2, TRT,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: