TESC Antibody (C-term) [APR05540G]

TESC Antibody (C-term) [APR05540G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This TESC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-116 amino acids from the C-terminal region of human TESC.

Cellular Localisation: Nucleus. Cytoplasm. Membrane; Lipid-anchor. Cell membrane. Cell projection, lamellipodium. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q9JKL5} Note=Colocalizes with SLC9A1 at the plasma membrane

Molecular Weight: 24750

Clone: Polyclonal

Gene Name: TESC

Gene ID: 54997

Function: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na (+) /H (+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.

Summary: Tissue Location: Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level) . Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Synonyms: Calcineurin B homologous protein 3, Tescalcin, TSC, TESC, CHP3