TESK1 Antibody (Center) [AMM08165G]

TESK1 Antibody (Center) [AMM08165G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This TESK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-215 amino acids from the Central region of human TESK1.

Cellular Localisation: Cytoplasm. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q63572} Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q63572}. Note=Colocalizes with SPRY4 in vesicular spots in the cytoplasm (PubMed:15584898) . Localized to F- actin-rich lamellipodia at the cell periphery following fibronectin- mediated cell adhesion of Schwann cells (By similarity) {ECO:0000250|UniProtKB:Q63572, ECO:0000269|PubMed:15584898}

Molecular Weight: 67684

Clone: Polyclonal

Gene Name: TESK1

Gene ID: 7016

Function: Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity) . Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity) . Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity) . Positively regulates integrin- mediated cell spreading, via phosphorylation of cofilin (PubMed:15584898) . Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865) . Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity) .

Summary: Tissue Location: Expressed in podocytes and renal tubular cells in the kidney (at protein level) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Dual specificity testis-specific protein kinase 1, Testicular protein kinase 1, TESK1