TFDP1 Antibody (N-Term) [APR33380G]

TFDP1 Antibody (N-Term) [APR33380G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This TFDP1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 83-114 amino acids from human TFDP1.

Cellular Localisation: Nucleus {ECO:0000250|UniProtKB:Q08639}. Cytoplasm {ECO:0000250|UniProtKB:Q08639}. Note=Shuttles between the cytoplasm and nucleus and translocates into the nuclear compartment upon heterodimerization with E2F1. {ECO:0000250|UniProtKB:Q08639}

Molecular Weight: 45070

Clone: Polyclonal

Gene Name: TFDP1

Gene ID: 7027

Function: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication (PubMed:8405995, PubMed:7739537) . The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812) .

Summary: Tissue Location: Highest levels in muscle. Also expressed in brain, placenta, liver and kidney. Lower levels in lung and pancreas. Not detected in heart

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Transcription factor Dp-1, DRTF1-polypeptide 1, DRTF1, E2F dimerization partner 1, TFDP1, DP1