TFEB Antibody | 6803

TFEB Antibody | 6803 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: N/A

Immunogen: Rabbit polyclonal TFEB antibody was raised against a 16 amino acid peptide near the carboxy terminus of human TFEB.
The immunogen is located within amino acids 390 - 440 of TFEB.

Research Area: Autophagy

Tested Application: E, IHC-P, IF

Application: TFEB antibody can be used for detection of TFEB by immunohistochemistry at 2.5 μg/ml.
Antibody validated: Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Specificiy: TFEB antibody is human specific. At least three isoforms of TFEB are known to exist.

Positive Control 1: Cat. No. 10-101 - Human Lung Tissue Slide

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: TFEB antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: TFEB antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: TFEB antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: TFEB Antibody: TCFEB, BHLHE35, ALPHATFEB, Transcription factor EB, Class E basic helix-loop-helix protein 35, bHLHe35

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The Transcription factor EB (TFEB) is a member in the basic helix-loop-helix leucine zipper superfamily of transcription factors that is translocated in a subset of renal tumors (1, 2) . Recent studies have shown that lysosomal biogenesis is regulated by TFEB (3) , which is in turn regulated by the mammalian target of rapamycin (mTOR) complex 1 (4) . Other evidence suggests that TFEB coordinates the major steps of the autophagic pathway by driving the expression of autophagy and lysosomal genes (5) .