TG101348 | 2314

TG101348 is a potent, and selective inhibitor of JAK2 (IC₅₀ = 3 nM). It has a 35- and 334-fold selectivity over JAK3 and JAK1, respectively.

TG101348 is a potent, and selective inhibitor of JAK2 (IC₅₀ = 3 nM). It has a 35- and 334-fold selectivity over JAK3 and JAK1, respectively.

2314 | TG101348 DataSheet

Alternate Name/Synonyms: N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide; SAR302503

Appearance: White solid

Formulation: N/A

CAS Number: 936091-26-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₃₆N₆O₃S

Molecular Weight: 524.68

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~100 mg/ml) or Ethanol (~ 20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent JAK2 inhibitor

MDL Number: MFCD09038564

PubChem CID: 16722836

SMILES: CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)OCCN4CCCC4

InChi: InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31)

InChi Key: JOOXLOJCABQBSG-UHFFFAOYSA-N