TGF beta Receptor II (phospho Ser225/250) Antibody | 79-819

TGF beta Receptor II (phospho Ser225/250) Antibody | 79-819 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: TGF beta Receptor II (phospho Ser225/250) antibody was raised against a peptide sequence around phosphorylation site of Serine 225/250 (D-R-S (p) -D-I) derived from Human TGF beta Receptor II.

Research Area: Phospho-Specific

Tested Application: IHC

Application: N/A

Specificiy: The antibody detects endogenous levels of TGF beta Receptor II only when phosphorylated at serine 225/250.

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: 64 kDa

Validation: N/A

Isoform: N/A

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+) , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Concentration: 1 mg/mL

Storage Condition: Store antibody at -20˚C for up to one year.

Alternate Name: TGF-betaR2, TGFR2, kinase TGF-beta-R2

User Note: N/A

BACKGROUND: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis.