TGF-beta2 Antibody | 5343R

The three mammalian isoforms of TGF-beta (TGF-beta1, TGF-beta2, TGF-beta3) signal thro?gh the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and would healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-beta isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. TGF-beta2 has been shown to exert suppressive effects on IL-2 dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development.

5343R | TGF-beta2 Antibody DataSheet

Antibody Target: TGF-b2

Target Alternative Name: TGF-b2, TGF b2 TGF-beta2, TGF beta-2, TGFbeta, TGFb2, transforming growth factor beta 2

Tag Line:

Category: TGF

Host: Rabbit

Isotype: Rabbit IgG

Species Reactivities: Human, mouse, rat

Immunogen Sequence: Synthetic peptide surrounding amino acid 366 of human TGF-?2

Accession #: BAG35929

Gene ID: 7042

Appearance: Colorless liquid

Form: Liquid

Concentration: 0.5 mg/ml

Formulation: 100 µg (0.5 mg/ml) peptide affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.

Purification: Affinity purified

Application: Western blot

Positive Control:

Application And Usages: Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes ~25kDa TGF-?2 of human, mouse, and rat origins. Reactivity to other species has not been tested.

Country of Animal Origin: China

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: Verified

Immunocytochemistry Verified: Not Verified

Immunofluorescence Verified: Not Verified

Immunoprecipitation Verified: Not Verified

FACS Verified: Not Verified

ELISA Verified: Not Verified

ChIP Verified: Not Verified

Dot Blot Verified:

Flow Cytometry Verified: Not Verified