TGFα polyclonal Antibody | BS91337

TGFα polyclonal Antibody | BS91337 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB ICC IF IHC IP

Application Range: WB:1:500 ICC:1:50-1:200 IHC:1:50-1:200

Background: Transforming growth factor-α (TGFα) is an acid- and heat-stable 50 amino acid protein originally found in rodents and humans. TGFα is 33% homologous at the amino acid level to epidermal growth factor (EGF) . TGFα binds to the EGF receptor, mediates tyrosine phosphorylation of the receptor and promotes anchorage-independent growth of normal rat fibroblasts in soft agar in the presence of transforming growth factor-β. TGFα is secreted by a variety of transformed cells and tumors, embryonic cells and some normal adult cells. TGFα bioactivity has been found in the urine of cancer patients. It has been suggested that it may act as an autocrine growth factor for the induction or maintenance of malignancy.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: TGFα polyclonal Antibody detects endogenous levels of TGFα protein.

Molecular Weight: 17 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: TGF-alpha, ETGF, TGFA, EGF like TGF, EGF-like TGF, ETGF, TFGA, TGF A, TGF type 1, TGF-alpha, Tgfa, TGFA, Transforming growth factor alpha, Transforming growth factor alpha precursor, Wa1, Waved 1,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: TGFβ Smad signaling,