TGFB2 Polyclonal Antibody | E-AB-40425

TGFB2 Polyclonal Antibody | E-AB-40425 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: BSC1 cell growth inhibitor, Cetermin, G-TSF, Glioblastoma-derived T-cell suppressor factor, GTSF, LAP, Latency-associated peptide, MGC116892, MGF, Milk growth factor, Polyergin, TGF-beta2, TGFB2, Transforming growth factor beta 2

Application: WB, IHC

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Signal Transduction, Stem Cells, Cancer, Metabolism

Background: This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.

Concentration: 0.95 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant Human Transforming growth factor beta-2 proprotein protein

Buffer: PBS with 0.05% Proclin300, 50% glycerol, pH7.3

Purification Method: Antigen Affinity Purification

Dilution: WB 1:500-1:2000 IHC 1:50-1:200

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 47, 50 kDa

Molecular Weight(Observed): 47 kDa