Description
An antimitotic alkaloid. Tubulin polymerization and microtubule assembly inhibitor and axonal cytoskeleton modulator; apoptosis inducer. Thiocolchicine-dimers were shown to be potent topoisomerase I inhibitors.
Thiocolchicine is an antimitotic alkaloid. Tubulin polymerization and microtubule assembly inhibitor and axonal cytoskeleton modulator; apoptosis inducer. Thiocolchicine-dimers were shown to be potent topoisomerase I inhibitors.
2213 | Thiocolchicine DataSheet
Alternate Name/Synonyms: 10-Demethoxy-10-methylthiocolchicine; NSC 186301
Appearance: Yellow solid
Formulation: N/A
CAS Number: 2730-71-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₂H₂₅NO₅S
Molecular Weight: 415.5
Cell-Permeable?: Yes
Purity: ³95% by NMR
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A tubulin polymerization and microtubule assembly inhibitor
MDL Number: N/A
PubChem CID: 546854
SMILES: CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)SC)OC)OC)OC
InChi: InChI=1S/C22H25NO5S/c1-12(24)23-16-8-6-13-10-18(26-2)21(27-3)22(28-4)20(13)14-7-9-19(29-5)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)
InChi Key: CMEGANPVAXDBPL-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24months |