Thiocolchicine | 2213

An antimitotic alkaloid. Tubulin polymerization and microtubule assembly inhibitor and axonal cytoskeleton modulator; apoptosis inducer. Thiocolchicine-dimers were shown to be potent topoisomerase I inhibitors.

Thiocolchicine is an antimitotic alkaloid. Tubulin polymerization and microtubule assembly inhibitor and axonal cytoskeleton modulator; apoptosis inducer. Thiocolchicine-dimers were shown to be potent topoisomerase I inhibitors.

2213 | Thiocolchicine DataSheet

Alternate Name/Synonyms: 10-Demethoxy-10-methylthiocolchicine; NSC 186301

Appearance: Yellow solid

Formulation: N/A

CAS Number: 2730-71-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₅NO₅S

Molecular Weight: 415.5

Cell-Permeable?: Yes

Purity: ³95% by NMR

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A tubulin polymerization and microtubule assembly inhibitor

MDL Number: N/A

PubChem CID: 546854

SMILES: CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)SC)OC)OC)OC

InChi: InChI=1S/C22H25NO5S/c1-12(24)23-16-8-6-13-10-18(26-2)21(27-3)22(28-4)20(13)14-7-9-19(29-5)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)

InChi Key: CMEGANPVAXDBPL-UHFFFAOYSA-N