THP polyclonal Antibody | BS7267

THP polyclonal Antibody | BS7267 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: WB

Application Range: WB 1:500 - 1:2000

Background: Tamm-Horsfall glycoprotein (also referred to as uromodulin or THP) is the most abundant protein found in normal urine. THP is expressed on the luminal surface of the membrane with the glycosyl phosphatidylinositol (GPI) anchor and excreted in urine at a rate of 50-100 mg per day. THP, uropontin and nephrocalcin are the three known urinary glycoproteins that affect the formation of calcium-containing kidney stones. THP is synthesized by kidney epithelial cells and is believed to play important and diverse roles in the urinary system,including renal water balance, immunosuppression, urinary stone formation and inhibition of bacterial adhesion. THP is nontoxic and blocks early events required for normal T cell proliferation in vitro.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: THP polyclonal Antibody detects endogenous levels of THP protein.

Molecular Weight: ~ 70 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Uromodulin; Tamm-Horsfall urinary glycoprotein; THP; UMOD

Immunogen: Recombinant full length Human THP.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: