Thymidine Kinase Antibody [3B3.E11] | 47-130

Thymidine Kinase Antibody [3B3.E11] | 47-130 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human

Homology: N/A

Immunogen: 5’-His-tagged recombinant human thymidine kinase.

Research Area: Cancer

Tested Application: N/A

Application: N/A

Specificiy: N/A

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: N/A

Clonality: Monoclonal

Clone: 3B3.E11

Isotype: IgG1

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS

Concentration: N/A

Storage Condition: This antibody is stable for at least one (1) year at -20˚C. Avoid multiple freeze- thaw cycles.

Alternate Name: DNA ligase 1, DNA ligase I,

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Thymidine kinase (TK) belongs to a group of enzymes such as dihydrofolate reductase, thymidylate synthase, and DNA polymerase that are involved in DNA synthesis and precursor production. High levels of these enzymes are present in proliferating cells, and low levels are found in resting cells, due to multiple regulatory mechanisms that ensure exclusive expression of these enzymes in replicating cells. TK is responsible for catalyzing the phosphorylation of thymidine, which functions as a part of the pyrimidine salvage pathway involved in DNA synthesis. The activities of enzymes such as TK are essential for the activation of several chemotherapeutically important nucleoside analogues that are administered as prodrugs.