TIAF Antibody | 7305

TIAF Antibody | 7305 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Homology: N/A

Immunogen: TIAF antibody was raised against a 16 amino acid peptide near the amino terminus of human TIAF .
The immunogen is located within the first 50 amino acids of TIAF.

Research Area: Apoptosis

Tested Application: E, WB, ICC

Application: TIAF Antibody can be used for detection of TIAF by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

Specificiy: Two alternatively spliced transcript variants encoding different isoforms have been identified.

Positive Control 1: Cat. No. 1204 - K562 Cell Lysate

Positive Control 2: Cat. No. 17-004 - K-562 Cell Slide

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 13 kDa
Observed: 14 kDa

Validation: N/A

Isoform: N/A

Purification: TIAF Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: TIAF Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: TIAF antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: TIAF Antibody: MAJN, SPR210, TGFB1-induced anti-apoptotic factor 1, 12 kDa TGF-beta-1-induced antiapoptotic factor

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: TIAF Antibody: TIAF-1 (TGFB1-induced anti-apoptotic factor 1) , also known as MYO18A, is a TGFB1-induced anti-apoptotic factor that functions to inhibit the cytotoxic effects of TNF-alpha, TRADD and FADD. It localizes to the nucleus and significantly up-regulated in activated helper T lymphocytes (TH2) in chronic kidney and liver allograft rejection. Suppression of TIAF1 expression by siRNA prevents UV irradiation-mediated p53 phosphorylation and nuclear translocation. TIAF1 is essential in the p53- and WOX1-mediated cell death and shows an aggregation-dependent control of tumor progression and metastasis, and regulation of cell death.