Description
TIAF Antibody | 7305 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human, Mouse
Homology: N/A
Immunogen: TIAF antibody was raised against a 16 amino acid peptide near the amino terminus of human TIAF .
The immunogen is located within the first 50 amino acids of TIAF.
Research Area: Apoptosis
Tested Application: E, WB, ICC
Application: TIAF Antibody can be used for detection of TIAF by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.
Specificiy: Two alternatively spliced transcript variants encoding different isoforms have been identified.
Positive Control 1: Cat. No. 1204 - K562 Cell Lysate
Positive Control 2: Cat. No. 17-004 - K-562 Cell Slide
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: Predicted: 13 kDa
Observed: 14 kDa
Validation: N/A
Isoform: N/A
Purification: TIAF Antibody is affinity chromatography purified via peptide column.
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: TIAF Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Condition: TIAF antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Alternate Name: TIAF Antibody: MAJN, SPR210, TGFB1-induced anti-apoptotic factor 1, 12 kDa TGF-beta-1-induced antiapoptotic factor
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: TIAF Antibody: TIAF-1 (TGFB1-induced anti-apoptotic factor 1) , also known as MYO18A, is a TGFB1-induced anti-apoptotic factor that functions to inhibit the cytotoxic effects of TNF-alpha, TRADD and FADD. It localizes to the nucleus and significantly up-regulated in activated helper T lymphocytes (TH2) in chronic kidney and liver allograft rejection. Suppression of TIAF1 expression by siRNA prevents UV irradiation-mediated p53 phosphorylation and nuclear translocation. TIAF1 is essential in the p53- and WOX1-mediated cell death and shows an aggregation-dependent control of tumor progression and metastasis, and regulation of cell death.