LBD
TIAM1 Antibody (C-term) [APR31897G]
- SKU:
- LBD-APR31897G
- Availability:
- Usually ships in 5 working days
Description
TIAM1 Antibody (C-term) [APR31897G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This TIAM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1478-1506 amino acids from the C-terminal region of human TIAM1.
Cellular Localisation: Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the boundary between cells with actin-rich protrusions (By similarity) . Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction
Molecular Weight: 177508
Clone: Polyclonal
Gene Name: TIAM1 {ECO:0000303|PubMed:7731688, ECO:0000312|HGNC:HGNC:11805}
Gene ID: 7074
Function: Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration.
Summary: Tissue Location: Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:2000
Synonyms: T-lymphoma invasion and metastasis-inducing protein 1, TIAM-1, TIAM1