TIAM2 Antibody (N-term) [AMM08187G]

TIAM2 Antibody (N-term) [AMM08187G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This TIAM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 357-385 amino acids of human TIAM2.

Cellular Localisation: Cytoplasm {ECO:0000250|UniProtKB:Q6ZPF3}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q6ZPF3}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q6ZPF3}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q6ZPF3}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q6ZPF3}. Perikaryon {ECO:0000250|UniProtKB:Q6ZPF3}

Molecular Weight: 190103

Clone: Polyclonal

Gene Name: TIAM2

Gene ID: 26230

Function: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane (By similarity) . Activates specifically RAC1, but not CDC42 and RHOA.

Summary: Tissue Location: Expressed in the occipital, frontal and temporal lobes, cerebellum, putamen and testis.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: T-lymphoma invasion and metastasis-inducing protein 2, TIAM-2, SIF and TIAM1-like exchange factor, TIAM2, KIAA2016, STEF