TIMP-2, human fibroblasts | 7788

Glycoprotein that belongs to a family which takes part in the activation and regulation of the MMP-activity. Forms a non-covalent stoichiometric complex with latent and active MMP's. Inhibits the activities of MMP-1, MMP-2, MMP-12 and transin.

7788 | TIMP-2 human fibroblasts DataSheet

Biomolecule/Target: N/A

Synonyms: Tissue Inhibitor of Matrix Metalloproteinases – 2

Alternates names: Metalloproteinase inhibitor 2 (CSC-21K) (Tissue inhibitor of metalloproteinases 2) (TIMP-2)

Taglines: An inhibitor of MMPs

NCBI Gene ID #: 7132

NCBI Gene Symbol: TNR1A

Gene Source: Human

Accession #: AAA36756

Recombinant: No

Source: Isolated from human fibroblasts

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: HPLC

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: The biological activity of sTNF-RI was determined by its inhibitory effect of the TNF- mediated cytotoxicity in murine L-929 cells. The ED for the effect in the presence of 0.25 ng/ml of recombinant TNF-, is 0.05 mg/ml.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 21.0 kDa

Concentration: 100 µg/ml

Appearance: Liquid

Physical form description: In 50 mM Tris-HCl, pH 7; 200 mM NaCl; 5 mM CaCl; 1 M ZnCl; 0.05% Brij 35; 0,05% NaN

Reconstitution Instructions: Reconstitute in 5 mM Tris, pH 8.0 to a concentration of 1 mg/ml. This solution can then be diluted into other aqueous buffers or stored at –4°C for 1 week or –20°C for future use.

Amino acid sequence: N/A