Tivozanib | B1545

Tivozanib (AV-951) is a potent and selective VEGFR inhibitor with IC₅₀ values of of 30, 6.5 15 nM, for VEGFR-1, VEGFR-2, and VEGFR-3, respectively. It also inhibits PDGFR and c-Kit, with lower activity observed against FGFR-1, Flt3, c-Met,EGFR and IGF-1R.

Tivozanib (AV-951) is a potent and selective VEGFR inhibitor with IC₅₀ values of of 30, 6.5 15 nM, for VEGFR-1, VEGFR-2, and VEGFR-3, respectively. It also inhibits PDGFR and c-Kit, with lower activity observed against FGFR-1, Flt3, c-Met,EGFR and IGF-1R.

B1545 | Tivozanib DataSheet

Alternate Name/Synonyms: 1-(2-chloro-4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-3-(5-methylisoxazol-3-yl)urea; AV 951; KRN951

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 475108-18-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₂H₁₉ClN₄O₅

Molecular Weight: 454.86

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO ( 10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective VEGFR inhibitor

MDL Number: N/A

PubChem CID: 9911830

SMILES: CC1=CC(=NO1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)Cl

InChi: InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28)

InChi Key: SPMVMDHWKHCIDT-UHFFFAOYSA-N