749
TLR4 Polyclonal Antibody | ABP57210
- SKU:
- 749-ABP57210
- Availability:
- Usually ships in 5 working days
Description
TLR4 Polyclonal Antibody | ABP57210 | Gentaur UK, US & Europe Distribution
Immunogen: Recombinant Protein
Product Category: Protein
Application: Protein General Reagents
Product Type: Primary Antibody
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: IHC-P
Application Note: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:200-1:500) .
Clonality: Polyclonal
Isotype: Rabbit IgG
Formulation: Liquid solution
Kit Component: N/A
Concentration: 1 mg/ml
Storage Buffer: PBS, pH 7.4, containing 0.02% Sodium Azide as preservative and 50% Glycerol.
Storage Instructions: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Shipping Condition: Gel pack with blue ice.
Background: The protein encoded by TLR4 (toll like receptor 4) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in TLR4 have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for TLR4.
Alternative Names: N/A
Precaution: The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.