TLR4 (S441) polyclonal Antibody | BS3489

TLR4 (S441) polyclonal Antibody | BS3489 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC IF

Application Range: WB 1:500 - 1:2000 IHC 1:100 - 1:200 IF 1:50 - 1:200

Background: Toll like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila toll is required for the anti fungal response, while the related 18 wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities have been implicated in the innate host defense to pathogens. TLR4 has been identified next to MD2 and CD14 as a receptor that is central to the innate immune response to lipopolysaccharides (LPS) of Gram negative bacteria.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: TLR4 (S441) polyclonal Antibody detects endogenous levels of TLR4 protein.

Molecular Weight: ~ 120 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Toll-like receptor 4; hToll; CD284; TLR-4

Immunogen: Synthetic peptide, corresponding to amino acids 421-470 of Human TLR4.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: PI3K AKT signaling,Protein Kinase C Signaling,Hypoxia Signaling,Translational Contral elF4 and p70 S6 Kinase,Inhibition of Apoptosis,Insulin &Glucose Signaling,MAPK Erk in Growth and Differentiation Pathway,Mitochondrial Control of Apoptosis,MTOR signaling,ErbB HER Signaling,