TMEM107 Antibody | 7483

TMEM107 Antibody | 7483 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: Predicted species reactivity based on immunogen sequence: Mouse: (86%) , Rat: (86%)

Immunogen: TMEM107 antibody was raised against a 19 amino acid peptide near the amino terminus of human TMEM107.
The immunogen is located within amino acids 20 - 70 of TMEM107 .

Research Area: Immunology

Tested Application: E, WB, IHC-P, IF

Application: TMEM107 antibody can be used for detection of TMEM107 by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Specificiy: TMEM107 antibody is human specific. At least two isoforms of TMEM107 are known to exist.

Positive Control 1: Cat. No. 1208 - THP-1 Cell Lysate

Positive Control 2: Cat. No. 11-521 - Human Lymphoid Tissue Tissue Slide

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 16 kDa
Observed: 19kDa

Validation: N/A

Isoform: N/A

Purification: TMEM107 Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: TMEM107 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: TMEM107antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: TMEM107 Antibody : GRVS638, PRO1268, Transmembrane protein 107

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Transmembrane protein 107 (TMEM 107) is critical for cilia formation and embryonic patterning (1) . It is a 139 amino acid transmembrane protein encoded by a gene that maps to human chromosome 17 which is associated with two key tumor suppressor genes p53 and BRCA1 (1, 2) . TMEM107 is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types (1, 3) . TMEM107 is also a strong candidate gene for central areolar choroidal dystrophy (CACD) (1-3) .