TMEM173 polyclonal Antibody | BS91357

TMEM173 polyclonal Antibody | BS91357 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB FC ICC/IF

Application Range: WB:1:500-1:1,000 FC:1:50-1:100 ICC:1:10-1:50

Background: Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta) . Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) . Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: TMEM173 polyclonal Antibody detects endogenous levels of TMEM173 protein.

Molecular Weight: N/A

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: hSTING, ERIS, hMITA, TMEM173, ERIS, MITA, STING, endoplasmic reticulum IFN stimulator, Endoplasmic reticulum interferon stimulator, ERIS, FLJ38577, hMITA, hSTING, Mediator of IRF3 activation, MITA, Mitochondrial mediator of IRF3 activation, MPYS, N terminal methionine proline tyrosine serine plasma membrane tetraspanner, NET23, Stimulator of interferon genes, Stimulator of interferon genes protein, STING, TM173, Tmem173, Transmembrane protein 173,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: