LBD
TMEM199 Antibody (N-term) [APR04540G]
- SKU:
- LBD-APR04540G
- Availability:
- Usually ships in 5 working days
Description
TMEM199 Antibody (N-term) [APR04540G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This TMEM199 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-75 amino acids from the N-terminal region of human TMEM199.
Cellular Localisation: Cytoplasmic vesicle, COPI-coated vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Partial colocalization with GOLGB1
Molecular Weight: 23130
Clone: Polyclonal
Gene Name: TMEM199 {ECO:0000303|PubMed:26833330, ECO:0000312|HGNC:HGNC:18085}
Gene ID: 147007
Function: Accessory component of the proton-transporting vacuolar (V) - ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe (2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (PubMed:28296633) . May be involved in Golgi homeostasis (PubMed:26833330) .
Summary: N/A
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Transmembrane protein 199, TMEM199, C17orf32