TMEM49 Antibody (C-term) [APR10490G]

TMEM49 Antibody (C-term) [APR10490G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This TMEM49 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 377-406 amino acids of human TMEM49.

Cellular Localisation: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q91ZQ0}; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Vacuole membrane {ECO:0000250|UniProtKB:Q91ZQ0}; Multi- pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein

Molecular Weight: 46238

Clone: Polyclonal

Gene Name: VMP1 {ECO:0000303|PubMed:28890335, ECO:0000312|HGNC:HGNC:29559}

Gene ID: 81671

Function: Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes (PubMed:33929485, PubMed:33850023) . Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine (PubMed:33929485, PubMed:33850023) . Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly (PubMed:28890335, PubMed:30093494, PubMed:30933966, PubMed:33929485, PubMed:33850023) . Regulates ATP2A2 activity to control ER-isolation membrane contacts for autophagosome formation (PubMed:28890335) . In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (PubMed:31526472, PubMed:33850023) . Modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335) . Plays an essential role in formation of cell junctions (PubMed:17724469) . Upon stress such as bacterial and viral infection, promotes formation of cytoplasmic vacuoles followed by cell death (By similarity) . Involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis (By similarity) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Vacuole membrane protein 1, Transmembrane protein 49, VMP1, TDC1, TMEM49