TMEM97 Antibody (N-term) [APR33328G]

TMEM97 Antibody (N-term) [APR33328G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M, Rat

Specificity: This TMEM97 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 22-56 amino acids from the N-terminal region of human TMEM97.

Cellular Localisation: Nucleus membrane; Multi-pass membrane protein. Rough endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Localized at cell membrane and in lysosomes in sterol-depleted cells when expression of endogenous TMEM97 is stimulated.

Molecular Weight: 20848

Clone: Polyclonal

Gene Name: TMEM97 (HGNC:28106)

Gene ID: 27346

Function: Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cancer cells (PubMed:28559337) . Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation (PubMed:23922215, PubMed:25620095) . Under investigation for its potential diagnostic and therapeutic uses (PubMed:23922215, PubMed:25620095) . May play a role as a regulator of cellular cholesterol homeostasis (PubMed:19583955) . May function as sterol isomerase (PubMed:25566323) . May alter the activity of some cytochrome P450 proteins (PubMed:22292588) .

Summary: Tissue Location: Widely expressed in normal tissues. Expressed in pancreatic, renal, breast, colon, ovarian surface epithelial (OSE) cells. Highly expressed in various proliferating cancer cells (PubMed:23922215) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1：1000

Synonyms: Transmembrane protein 97, Protein MAC30, TMEM97, MAC30