TMP-195 | B1860

TMP-195 is a potent and selective class IIa HDAC inhibitor with IC₅₀ values of 59, 60, 26, and 15 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively. TMP195 induces the recruitment and differentiation of highly phagocytic and stimulatory macrophages within tumors.

TMP-195 is a potent and selective class IIa HDAC inhibitor with IC₅₀ values of 59, 60, 26, and 15 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively. TMP195 induces the recruitment and differentiation of highly phagocytic and stimulatory macrophages within tumors.

B1860 | TMP-195 DataSheet

Alternate Name/Synonyms: N-(2-methyl-2-(2-phenyloxazol-4-yl)propyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1314891-22-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₃H₁₉F₃N₄O₃

Molecular Weight: 456.42

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective class IIa HDAC inhibitor

MDL Number: N/A

PubChem CID: 67324851

SMILES: CC(C)(CNC(=O)C1=CC=CC(=C1)C2=NOC(=N2)C(F)(F)F)C3=COC(=N3)C4=CC=CC=C4

InChi: InChI=1S/C23H19F3N4O3/c1-22(2,17-12-32-20(28-17)14-7-4-3-5-8-14)13-27-19(31)16-10-6-9-15(11-16)18-29-21(33-30-18)23(24,25)26/h3-12H,13H2,1-2H3,(H,27,31)

InChi Key: QTCSXAUJBQZZSN-UHFFFAOYSA-N