Description
TMP-195 is a potent and selective class IIa HDAC inhibitor with IC₅₀ values of 59, 60, 26, and 15 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively. TMP195 induces the recruitment and differentiation of highly phagocytic and stimulatory macrophages within tumors.
TMP-195 is a potent and selective class IIa HDAC inhibitor with IC₅₀ values of 59, 60, 26, and 15 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively. TMP195 induces the recruitment and differentiation of highly phagocytic and stimulatory macrophages within tumors.
Alternate Name/Synonyms: N-(2-methyl-2-(2-phenyloxazol-4-yl)propyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1314891-22-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₂₃H₁₉F₃N₄O₃
Molecular Weight: 456.42
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent and selective class IIa HDAC inhibitor
MDL Number: N/A
PubChem CID: 67324851
SMILES: CC(C)(CNC(=O)C1=CC=CC(=C1)C2=NOC(=N2)C(F)(F)F)C3=COC(=N3)C4=CC=CC=C4
InChi: InChI=1S/C23H19F3N4O3/c1-22(2,17-12-32-20(28-17)14-7-4-3-5-8-14)13-27-19(31)16-10-6-9-15(11-16)18-29-21(33-30-18)23(24,25)26/h3-12H,13H2,1-2H3,(H,27,31)
InChi Key: QTCSXAUJBQZZSN-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |