TNFAIP8L3 Antibody (Center) [APR03623G]

TNFAIP8L3 Antibody (Center) [APR03623G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This TNFAIP8L3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-164 amino acids from the Central region of human TNFAIP8L3.

Cellular Localisation: Cytoplasm. Cell membrane {ECO:0000250|UniProtKB:Q3TBL6}. Note=On PDGF activation, translocates from cytoplasm to plasma membrane {ECO:0000250|UniProtKB:Q3TBL6}

Molecular Weight: 32659

Clone: Polyclonal

Gene Name: TNFAIP8L3

Gene ID: 388121

Function: Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4, 5- bisphosphate and phosphatidylinositol 3, 4, 5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling.

Summary: Tissue Location: Widely expressed (at protein level) (PubMed:25479791) . Highly expressed in most carcinoma cell lines (PubMed:25479791, PubMed:25242044) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Tumor necrosis factor alpha-induced protein 8-like protein 3, TNF alpha-induced protein 8-like protein 3, TNFAIP8-like protein 3, TNFAIP8L3