TNFR2 polyclonal Antibody | BS91362

TNFR2 polyclonal Antibody | BS91362 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC/IF IHC FC IP

Application Range: WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100 IP:1:10-1:50

Background: Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated through two distinct cell surface receptors. These receptors, designated TNF-R1 and TNF-R2, are expressed on most cell types. The majority of TNF functions are primarily mediated through TNF-R1, while signaling through TNF-R2 occurs less extensively and is confined to cells of the immune system. Both of these proteins belong to the growing TNF and nerve growth factor (NGF) receptor superfamily, which includes FAS, CD30, CD27 and CD40. The members of this superfamily are type I membrane proteins that share sequence homology confined to the extracellular region. TNF-R1 shares a motif termed the "death domain" with FAS and three structurally unrelated signaling proteins, TRADD, FADD and RIP (1,3-8) . This death domain is required for transduction of the apoptotic signal.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: TNFR2 polyclonal Antibody detects endogenous levels of TNFR2 protein.

Molecular Weight: 73 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: TNF-R2, TNF-RII, TNFR-II, TNFRSF1B, CD120b, p75, p75 TNF receptor, p75TNFR, p80 TNF alpha receptor, p80 TNF-alpha receptor, Soluble TNFR1B variant 1, TBP-2, TBPII, TNF R II, TNF R2, TNF R75, TNF-R2, TNF-RII, TNFBR, TNFR-II, TNFR1B, TNFR2, TNFR80, TNFRII, Tnfrsf1b, TNR1B, Tumor necrosis factor beta receptor, Tumor necrosis factor receptor 2, Tumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor type II, Tumor necrosis factor-binding protein 2,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: