TNFSF13B polyclonal Antibody | BS7904

TNFSF13B polyclonal Antibody | BS7904 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: WB,IHC,IF

Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Background: TNF cytokine family member TALL-1 (also designated BAFF, THANK and BLyS), is a type II membrane protein that shares characteristics with other members of the tumor necrosis factor (TNF) cytokine family. TALL-1 is expressed abun-dantly in peripheral blood leukocytes, monocytes and macrophages. TALL-1 is critically involved in the regulation of infections, inflammation, autoimmune diseases and tissue homeostasis. TALL-1 is a potent B cell stimulatory factor which is functionally involved in B cell proliferation and may be a primary mediator in B cell-associated autoimmune diseases. The C-terminal extracellular domain has b jelly roll topography and is important in ligand trimerization. The binding of the ligand to its respective receptor induces oligomerization, initiating downstream signaling events. Intrinsic to oligomerization is the formation of the receptor binding site at the junction between neighboring subunits, creating a multivalent ligand.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: TNFSF13B polyclonal Antibody detects endogenous levels of TNFSF13B protein.

Molecular Weight: ~ 42 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: TNFSF13B; BAFF; BLYS; CD257; DTL; TALL-1; TALL1; THANK; TNFSF20; TNLG7A; ZTNF4

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 76-285 of human TNFSF13B (NP_006564.1) .

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A