TNFSF14 polyclonal Antibody | BS65551

TNFSF14 polyclonal Antibody | BS65551 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Mouse

Application: WB,

Application Range: WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

Background: LIGHT protein is a type II transmembrane protein and a tumor necrosis factor (TNF) ligand superfamily member (TNFSF14) . LIGHT is expressed on activated T cells and immature dendritic cells and its receptors have been identified as lymphotoxin-Beta receptor (LTBetaR) and the herpesvirus entry mediator (HVEM), both of which lack the cytoplasmic sequence termed as "death domain." LIGHT is first identified as HVEM ligand (HVEM-L) and a deterrent to herpesvirus infection according to its ability to compete with HSV glycoprotein D for HVEM binding. As a T cell-derived costimulatory ligand, TNFSF14 plays a crucial role in T cell activation and proliferation by LIGHT-LTBetaR interaction, and it is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. Additionally, recent studies also establish a direct role for LIGHT in NK activation/expansion via LIGHT-HVEM interaction, and thus breaking T-cell tolerance at the tumor site. Accordingly, LIGHT is suggested to be involved in CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Although known as lymphotoxin-Gamma, LIGHT plays a minimal role in lymphoid tissue development in contrast with LT-Alpha and Beta. This protein was also demonstrated to inhibit TNF-Alpha-mediated but not Fas- or TRAIL-mediated apoptosis of human primary hepatocytes.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: TNFSF14 polyclonal Antibody detects endogenous levels of TNFSF14 protein.

Molecular Weight: ~26kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CD 258; CD258; CD258 antigen; Delta transmembrane LIGHT; Herpes virus entry mediator ligand; Herpesvirus entry mediator A; Herpesvirus entry mediator ligand; herpesvirus entry mediator-ligand; HVEM L; HVEM-L; HVEML; Ligand for herpesvirus entry mediator; LIGHT; LTg; soluble form; TNF14; TNF14_HUMAN; TNFSF 14; TNFSF14 protein; TR 2; TR2; Tumor necrosis factor (ligand) superfamily, member 14; Tumor necrosis factor ligand superfamily member 14; Tumor necrosis factor ligand superfamily, member 14; Tumor necrosis factor receptor like 2; tumor necrosis factor receptor-like 2; Tumor necrosis factor superfamily member 14; Tumor necrosis factor superfamily member LIGHT.

Immunogen: KLH conjugated synthetic peptide derived from mouse TNFSF14:59-130/239

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: